Right-back Klaiber, 26, has penned a three-year deal with the option of a fourth year.
Utrecht will receive around €5m for Klaiber, who spent 13 years with the club and made over 150 appearances.
We all want to play for Ajax 😉#Klaiber2024
— AFC Ajax (@AFCAjax) October 1, 2020
Klaiber was in the Ajax youth system in the 2005-06 season, but was considered too light and left the club.
At Utrecht, he forged a good reputation with the fans and often spoke negatively about his new club Ajax.
Ajax coach Erik ten Hag played a big role in the signing as he is friendly with Klaiber from his time in charge at Utrecht.
Klaiber fills a vacancy left by Dest, whose €21m-plus move to Barcelona was made official today.