The Spaniards will be without Alberto Moreno for six months after he underwent surgery for a torn ACL.
And they have identified De Sciglio, 27, as a fitting replacement for the former Liverpool left-back.
Talks are at an early stage with Villarreal requesting information from Juve to understand how feasible a deal is.
It is not yet clear whether Villarreal are pursuing a permanent or loan move for De Sciglio.
De Sciglio had an injury-hit 2019/20 season with the Old Lady, making only nine Serie A appearances.