Sources close to the negotiations say a deal for 25-year-old Santamaria should be done soon.
However, Angers have released a statement saying Freiburg will have to improve their first offer of €11m, which has been rejected.
The talented defensive midfielder has made nearly 150 appearances for Angers since joining from Tours in 2016.
Til due for medical
Til, 22, was of interest to PSV Eindhoven but has chosen to play for SCF in Germany’s top flight.
The Zambia-born midfielder, a one-time Dutch international, is due for a medical at Freiburg ahead of his loan signing.
He is currently nursing an ankle injury but it will not stand in the way of his move to the Schwarzwald-Stadion.