The Old Lady want to refresh their ageing squad and have already let Blaise Matuidi leave for Inter Miami.
Higuain (32) and Khedira (33) are both under contract for another year and Juventus plan to give them pay-offs to leave early.
Khedira hasn’t appeared for Juventus since December due to injury, but Higuain has continued to play an active role.
Perin and Rugani to follow?
It isn’t just the 30-plus group facing the chop as part of Andrea Pirlo’s Juventus makeover.
Perin’s agent held talks with sporting director Fabio Paratici on Friday to find a solution for the goalkeeper.
Centre-back Daniele Rugani, 26, could also possibly leave, but rumours of a swap deal with Arsenal for Hector Bellerin are unconfirmed.