— Alfredo Pedullà (@AlfredoPedulla) August 18, 2020
Ghoulam, 29, is represented by agent Jorge Mendes who has a close working relationship with Wolves.
And led by Mendes, talks between Wolves and Napoli got underway on Tuesday to discuss the terms of a transfer.
No agreement has been reached yet with talks at an early stage, but Wolves have a concrete interest in the Algerian international.
The English club need a left-back with Jonny Castro Otto out for months with a serious injury.
Since then, he has been troubled by knee and ankle injuries, limiting his appearances for Napoli.
Ghoulam is out of contract in June 2022 and Napoli are open to a sale this summer.