Ralph Hasenhuttl will also lose Kyle Walker-Peters at the end of the season when the loanee returns to Tottenham.
And 22-year-old Zeefuik, who joined Groningen from Ajax in 2018, is in Southampton’s crosshairs as the man to fill the void.
Zeefuik, a Dutch under-21 international, is entering the final year of his contract and will be sold this summer.
Groningen sporting director Mark-Jan Fledderus has also said that there is interest from Germany.
However, Southampton can offer the best salary and the Premier League would appeal to Zeefuik.
Zeefuik has made 26 appearances in the Eredivisie this season, assisting two goals.